Ensure Close Monitoring With Prolia in Kidney Disease

February 2023

You’ll hear about the risk of severely low calcium with Prolia (denosumab) for osteoporosis...due to a recent FDA alert.

Prolia labels already warn that it can cause low calcium in about 2 in 100 patients...because it reduces calcium mobilization from bone. And the risk is higher in severe kidney disease.

But Prolia is often used in kidney disease...since bisphosphonates generally shouldn’t be if CrCl is below 30 to 35 mL/min.

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