Be on the Lookout for Interactions With St. John’s Wort

December 2023

Questions often come up about whether St. John’s wort works for depression or other uses.

St. John’s wort is derived from a European plant. It is so named because it begins to flower near the date of St. John the Baptist’s feast.

Effectiveness. Explain that oral St. John’s wort extract is likely effective for mild or moderate depression.

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Table of Contents

Antihypertensives Answer Common Questions About First-Line BP Meds
Hypertension Use a Conservative Approach for Most Inpatient Hypertension
Naloxone Compare Nalmefene and Naloxone for Opioid Overdose Reversal
Diabetes Navigate Risk of Ketoacidosis Due to an SGLT2 Inhibitor
Cardiology Know the Role of Colchicine for Chronic Coronary Disease
Infectious Diseases Give Guidance About At-Home Tests for Respiratory Viruses
Communication Continue to Reinforce Using Inclusive Language
NatMed Spotlight Be on the Lookout for Interactions With St. John’s Wort