Don't Jump to Potassium Binders When ACEIs or ARBs Cause Hyperkalemia

April 2019

New Rx Lokelma (loh-KEL-mah) will pique interest in the role of potassium binders to treat CHRONIC hyperkalemia due to ACEIs or ARBs.

Think of Lokelma (sodium zirconium cyclosilicate) as most similar to sodium polystyrene sulfonate (Kayexalate, etc) for hyperkalemia.

Both exchange sodium to bind potassium...Lokelma also exchanges hydrogen. But Lokelma may cause fewer GI side effects.

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Table of Contents

Measles Address Measles Vaccine Concerns and Promote Immunization
Edema Evaluate Whether Peripheral Edema Is Due to Meds
Migraine Consider Triptans for Kids With Migraines
Anxiety Think of Buspirone as a Second- or Third-Line Option for Managing Anxiety
Osteoarthritis Weigh Benefits and Risks of Intra-Articular Injections for Osteoarthritis
Ulcerative Colitis Sort Through Treatments for Ulcerative Colitis
COPD Stick With LAMA Inhalers Instead of Nebulized Yupelri for Most COPD Patients
Hyperkalemia Don't Jump to Potassium Binders When ACEIs or ARBs Cause Hyperkalemia
Oral Health Stick With a Simple Formula if You Prescribe Magic Mouthwash
Veterinary Medicine Keep Pet Rxs in Mind as Another Source of Controlled Substance Diversion